Anti-Pin1 (Peptidyl-prolyl cis/trans Isomerase NIMA-interacting 1)

Anti-Pin1 (Peptidyl-prolyl cis/trans Isomerase NIMA-interacting 1)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
P4186-90A.40 40 µg - -

3 - 19 business days*

346.00€
 
PIN1 is an essential peptidyl-prolyl isomerase that regulates mitosis, presumably by interacting... more
Product information "Anti-Pin1 (Peptidyl-prolyl cis/trans Isomerase NIMA-interacting 1)"
PIN1 is an essential peptidyl-prolyl isomerase that regulates mitosis, presumably by interacting with NIMA and attenuating its mitosis-promoting activity. It displays a preference for an acidic residue N-terminal to the isomerized proline bond. It catalyzes pSer/Thr-Pro cis/trans isomerizations. PIN1 has been implicated in tau pathologies that underlie Alzheimer's disease. PIN1 binds to tau-phosphorylated sites, specifically on the Thr231-Pro site, where it induces conformational changes. PIN1 may be pivotal in maintaining normal neuronal function and preventing age-dependent neurodegeneration. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 0.05-0.2ug/ml, Western Blot: 0.5-1ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: EC=5.2.1.8, Anti-PPIase Pin1, Anti-Rotamase Pin1, Anti-Peptidyl-prolyl cis-trans isomerase Pin1, Anti-Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Supplier: United States Biological
Supplier-Nr: P4186-90A

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide within residues 50-100 of human PIN1 protein (Swiss Prot: Q13526).
Purity: Purified by immunoaffinity chromatography.
Format: Affinity Purified

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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