Anti-PIAS3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA006389.25	25 µl		-		7 - 10 business days*		369.00€
ATA-HPA006389.100	100 µl		-		7 - 10 business days*		491.00€

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Protein function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase,... more

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Product information "Anti-PIAS3"

Protein function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 96% and to rat: 93%

Keywords:	Anti-PIAS3, EC=2.3.2.-, Anti-E3 SUMO-protein ligase PIAS3, Anti-E3 SUMO-protein transferase PIAS3, Anti-Protein inhibitor of activated STAT protein 3
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA006389

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: PTKKHCSVTS AAIPALPGSK GVLTSGHQPS SVLRSPAMGT LGGDFLSSLP LHEYPPAFPL GADIQGLDLF SFLQTESQHY GPSVITSLDE QDALGHFFQY RGTPSHFLGP LAPTLGSSHC SATPAPPPGR VSSIVAPG (ATA-APrEST88606)