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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R30480 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Phosphatidylinositol 3-kinase regulatory... more
Product information "Anti-PI3K (p85 alpha)"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene. The PI3K p85 subunit family has two closely related members, alpha and beta. Both cDNAs encode p85 subunits, each of which is a 724-amino acid polypeptide. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Protein function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). [The UniProt Consortium]
Keywords: | Anti-GRB1, Anti-PIK3R1, Anti-PI3-kinase subunit p85-alpha, Anti-PI3K regulatory subunit alpha, Anti-PI3-kinase regulatory subunit alpha, Anti-PtdIns-3-kinase regulatory subunit alpha, Anti-PtdIns-3-kinase regulatory subunit p85-alpha, PI3K Antibody (p85 a |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R30480 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Amino acids 65-80 (ERGDFPGTYVEYIGRK-alpha subunit specific) was used as the immunogen for this PI3K antibody (100% human, mouse and rat). |
Format: | Purified |
Database Information
KEGG ID : | K02649 | Matching products |
UniProt ID : | P27986 | Matching products |
Gene ID | GeneID 5295 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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