Anti-Phosphodiesterase 11A (PDE11A, Dual 3',5'-Cyclic-AMP and -GMP Phosphodiesterase 11A, cAMP and c

PDE11A is a 100kD cyclic nucleotide phosphodiesterase, which catalyzes the hydrolysis of cAMP and cGMP. PDE11A is thought to be involved in multiple physiological processes in various organs. PDE11A is calmodulin dependent and exists as four splice variants (PDE11A1-PDE11A4). Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:2000 , Western Blot: 0.5-1.5ug/ml, Immunohistochemistry (Formalin-fixed, paraffin-embedded): 10ug/ml , Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.