Anti-phospho-PERK (Thr982)

Anti-phospho-PERK (Thr982)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG66268.100 100 µl - -

6 - 14 business days*

624.00€
 
Protein function: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit... more
Product information "Anti-phospho-PERK (Thr982)"
Protein function: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)- induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function. [The UniProt Consortium]
Keywords: Anti-phospho-PEK, Anti-phospho-HsPEK, Anti-phospho-EIF2AK3, EC=2.7.11.1, Anti-phospho-Pancreatic eIF2-alpha kinase, Anti-phospho-PRKR-like endoplasmic reticulum kinase, Anti-phospho-Eukaryotic translation initiation factor 2-alpha kinase 3
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG66268

Properties

Application: IHC (paraffin)
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: KLH-conjugated phospho-specific peptide around Thr982 (RHT(p)GQ) of Human PERK
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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