Anti-Phorbolin 1 / APOBEC3A

In 1X PBS, pH 7.4, with 0.09% sodium azide. Phorbolin 1/PHO1/APOBEC3A/Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A is part of a family of enzymes that are involved in the editing of RNA and DNA molecules. Phorbolin 1/APOBEC3A specifically acts as a barrier to prevent the replication of viral DNA within cells, making it a crucial component of the innate immune system. It also plays a pivotal role in preventing the development of certain cancers. Studies have shown that this protein can inhibit the growth of cancer cells by inducing mutations in their genetic material. Protein function: DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T- cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. [The UniProt Consortium]