Anti-PHLPP1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
600-401-DM2	100 µg		-	-	6 - 10 business days*		848.00€

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Anti-PHLPP1 Antibody was affinity purified from monospecific antiserum by immunoaffinity... more

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Product information "Anti-PHLPP1"

Anti-PHLPP1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least four isoforms are known to exist, this antibody will only detect the largest isoform. PHLPP1 antibody is predicted to not cross react with PHLPP2. Protein function: Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts. [The UniProt Consortium]

Keywords:	Anti-hSCOP, Anti-PHLPP1, Anti-KIAA0606, EC=3.1.3.16, Anti-PH domain-containing family E member 1, Anti-Suprachiasmatic nucleus circadian oscillatory protein, Anti-Pleckstrin homology domain-containing family E member 1, Anti-PH domain leucine-rich repeat-
Supplier:	Rockland Immunochemicals
Supplier-Nr:	600-401-DM2

Properties

Application:	ELISA, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	18 amino acid synthetic peptide near the N-terminus of human PHLPP1.
Format:	Purified