Anti-PGAM2 / Phosphoglycerate mutase 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PGAM2 antibody targets Phosphoglycerate mutase 2, encoded by the PGAM2 gene. Phosphoglycerate mutase 2 is a cytoplasmic enzyme that catalyzes the reversible interconversion of 3-phosphoglycerate and 2-phosphoglycerate during glycolysis. As a muscle-enriched isoform of phosphoglycerate mutase, PGAM2 plays a critical role in regulating glycolytic flux in tissues with high energetic demand.Functionally, Phosphoglycerate mutase 2 contributes to efficient ATP production by facilitating a key step in the central glycolytic pathway. Its activity supports rapid energy generation required for muscle contraction and other energy-intensive cellular processes. A PGAM2 antibody supports studies focused on carbohydrate metabolism, glycolytic regulation, and metabolic adaptation in differentiated tissues.PGAM2 is predominantly localized to the cytoplasm, consistent with its role in glycolysis. Although highly enriched in skeletal and cardiac muscle, PGAM2 expression can also be detected in other cell types under conditions that demand increased glycolytic activity. This distribution reflects a balance between tissue specialization and broader metabolic responsiveness.From a disease-related perspective, altered PGAM2 expression or activity has been investigated in muscle disorders, metabolic disease, and cancer. Changes in glycolytic enzyme expression can influence cellular energy balance, proliferation, and stress tolerance. As such, Phosphoglycerate mutase 2 is frequently studied in contexts linking metabolism to disease-associated phenotypes.At the molecular level, Phosphoglycerate mutase 2 functions as a dimeric enzyme and contains conserved catalytic residues required for phosphotransfer activity. Its apparent behavior in biochemical assays may vary depending on metabolic state and post-translational regulation without altering its primary structure. PGAM2 antibody reagents enable investigation of glycolytic enzyme regulation and cellular metabolism, with NSJ Bioreagents providing reagents intended for research use.