Anti-pfo

pfo Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Clostridium perfringens and for use in ELISA, WB applications. pfo Antibody is a high quality polyclonal antibody for research use only.. Protein function: A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol-containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A major conformational change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host cell membranes, membrane insertion and pore formation, cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation. [The UniProt Consortium]