Anti-PEX5 / Peroxisomal biogenesis factor 5

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PEX5 antibody targets Peroxisomal biogenesis factor 5, encoded by the PEX5 gene. Peroxisomal biogenesis factor 5 is a cytoplasmic protein that functions as the primary receptor for peroxisomal targeting signal 1 (PTS1) containing proteins. By recognizing the C-terminal PTS1 motif on newly synthesized matrix proteins, PEX5 mediates their delivery from the cytosol to the peroxisomal membrane for import into the peroxisome matrix.Functionally, Peroxisomal biogenesis factor 5 operates as a shuttling receptor that binds cargo proteins in the cytoplasm and docks at the peroxisomal membrane through interactions with other peroxins. Following cargo release into the peroxisome, PEX5 is recycled back to the cytosol, allowing repeated rounds of protein import. A PEX5 antibody supports studies focused on peroxisomal protein trafficking, organelle biogenesis, and intracellular transport mechanisms.PEX5 is predominantly localized to the cytoplasm but transiently associates with the peroxisomal membrane during active import cycles. Its dynamic localization reflects its role as a transport receptor rather than a static structural component of the organelle. Through regulation of matrix protein import, Peroxisomal biogenesis factor 5 supports essential peroxisomal functions, including fatty acid beta-oxidation, lipid metabolism, and reactive oxygen species detoxification.From a disease-related perspective, disruption of PEX5 function has been linked to peroxisome biogenesis disorders, in which impaired import of matrix enzymes leads to severe metabolic dysfunction. Altered expression or activity of PEX5 can compromise peroxisomal integrity and downstream metabolic pathways, making it an important target in studies of inherited metabolic disease and organelle dysfunction.At the molecular level, Peroxisomal biogenesis factor 5 contains conserved domains required for PTS1 recognition and interaction with peroxisomal membrane components. Its apparent behavior in experimental systems may vary with cellular metabolic state and import demand without changes to its primary structure. PEX5 antibody reagents enable investigation of peroxisomal protein import and organelle biogenesis, with NSJ Bioreagents providing reagents intended for research use.