Anti-Perforin (human), Biotin Conjugated Clone B-D48 [Mouse]

Specificity: Recognises human perforin, a 70kDa protein, Format: Phosphate-buffered saline. With 1% BSA and 0,09% Sodium Azide, Working Dilution: The suggested coating concentration range below should be optimised by each laboratory for each application. ELISA/ELISpot: 0,05-0,5µg/ml, Storage: Store at +2-8°C for 12 months. For longer storage, freeze aliquots, Application Notes: This Antibody can be used as Detection in a human **** sandwich Immunoassay to detect human **** in combination with human **** Capture Antibody (Cat n° ***.***.***). The suggested coating concentration range below should be optimised by each laboratory for each application. Protein function: Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. [The UniProt Consortium]