Anti-PECAM1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-15822.20 20 µl -

7 - 16 business days*

71.00€
E-AB-15822.60 60 µl -

7 - 16 business days*

143.00€
E-AB-15822.120 120 µl -

7 - 16 business days*

238.00€
E-AB-15822.200 200 µl -

7 - 16 business days*

396.00€
 
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils,... more
Product information "Anti-PECAM1"
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. Protein function: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells, PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock- induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis. [The UniProt Consortium]
Keywords: Anti-CD31, Anti-PECA1, Anti-PECAM1, Anti-GPIIA', Anti-PECAM-1, Anti-EndoCAM, Anti-Platelet endothelial cell adhesion molecule, PECAM1 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-15822

Properties

Application: WB, IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: Synthetic peptide of human PECAM1
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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