Anti-PEA15

In 1X PBS, pH 7.4, with 0.09% sodium azide. PEA-15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes. Protein function: Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. [The UniProt Consortium]