Anti-PDZK1

Anti-PDZK1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-60897.60 60 µl -

7 - 16 business days*

198.00€
E-AB-60897.120 120 µl -

7 - 16 business days*

317.00€
E-AB-60897.200 200 µl -

7 - 16 business days*

525.00€
 
This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules... more
Product information "Anti-PDZK1"
This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Protein function: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. [The UniProt Consortium]
Keywords: Anti-CAP70, Anti-PDZK1, Anti-NHERF-3, Anti-NaPi-Cap1, Anti-PDZ domain-containing protein 1, Anti-CFTR-associated protein of 70 kDa, Anti-Na(+)/H(+) exchanger regulatory factor 3, Anti-Sodium-hydrogen exchanger regulatory factor 3, PDZK1 Polyclonal Antibod
Supplier: Elabscience
Supplier-Nr: E-AB-60897

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Recombinant protein of human PDZK1

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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