Anti-PDE12

Anti-PDE12
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-CAB17270.20 20 µl -

9 - 20 business days*

103.00€
 
Protein function: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the... more
Product information "Anti-PDE12"
Protein function: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:30389976, PubMed:26055709). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). [The UniProt Consortium]
Keywords: Anti-PDE12, Anti-2-PDE, Anti-2'-PDE, Anti-Mitochondrial deadenylase, Anti-2',5'-phosphodiesterase 12
Supplier: Assay Genie
Supplier-Nr: CAB17270

Properties

Application: WB, IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: mouse, rat

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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