Anti-PDE12

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA043171.25	25 µl		-		7 - 10 business days*		246.00€
ATA-HPA043171.100	100 µl		-		7 - 10 business days*		491.00€

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Protein function: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the... more

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Product information "Anti-PDE12"

Protein function: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:30389976, PubMed:26055709). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 92% and to rat: 97%

Keywords:	Anti-2-PDE, Anti-PDE12, Anti-2'-PDE, Anti-Mitochondrial deadenylase, Anti-2',5'-phosphodiesterase 12
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA043171

Properties

Application:	IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: CGDFNSTPST GMYHFVINGS IPEDHEDWAS NGEEERCNMS LTHFFKLKSA CGEPAYTNYV GGFHGCLDYI FIDLNALEVE QVIPLPSHEE VTT (ATA-APrEST84143)