Anti-PCDHA11 / Protocadherin alpha 11

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PCDHA11 antibody detects Protocadherin alpha-11, encoded by the PCDHA11 gene on chromosome 5q31.3. PCDHA11 antibody is used in neuroscience and developmental biology, as PCDHA11 belongs to the protocadherin alpha gene cluster that encodes cadherin-like cell adhesion proteins. These molecules are highly expressed in the nervous system, where they contribute to neuronal diversity, connectivity, and synapse specification. The protocadherin cluster generates molecular diversity through combinatorial expression, enabling neurons to form specific connections.Structurally, Protocadherin alpha-11 is a ~110 kDa type I transmembrane protein containing six extracellular cadherin repeats, a single-pass transmembrane domain, and a short cytoplasmic tail. The extracellular domains mediate calcium-dependent homophilic adhesion, while the cytoplasmic domain interacts with signaling molecules and cytoskeletal regulators. PCDHA11 is expressed predominantly in brain tissue, including cortex and hippocampus.Functionally, PCDHA11 contributes to neuronal self-recognition and synapse formation. By expressing unique combinations of protocadherins, neurons establish cell-specific adhesion codes that guide connectivity. PCDHA11 also participates in dendritic arborization and neural circuit refinement. Researchers use PCDHA11 antibody to study neural adhesion, brain development, and synaptic patterning.Clinically, protocadherins have been linked to neurodevelopmental disorders, epilepsy, and autism spectrum disorders. Altered expression or mutation of PCDHA11 may disrupt neuronal connectivity and contribute to cognitive dysfunction. Because protocadherins influence synaptic diversity, they are considered candidates for neurological disease biomarkers. NSJ Bioreagents offers PCDHA11 antibody for research in developmental neuroscience and neurogenetics.Experimentally, PCDHA11 antibody is applied in western blotting to detect the ~110 kDa protein, in immunohistochemistry to visualize brain expression, and in immunofluorescence microscopy to examine synaptic localization. Co-immunoprecipitation with PCDHA11 antibody identifies interaction partners in cadherin and cytoskeletal networks.