Anti-PAX8 / Paired box gene 8, clone MSVA-708R

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Paired box protein Pax-8 (PAX8) is a nuclear transcription factor encoded by the PAX8 gene and a member of the paired box (PAX) family, functioning in epithelial lineage specification within thyroid, renal, and Mullerian-derived tissues. It regulates transcriptional programs that define cellular identity and differentiation. PAX8 Antibody for IHC is specifically optimized for immunohistochemical detection in formalin-fixed, paraffin-embedded tissues, where preservation of morphology and nuclear staining detail is essential for accurate interpretation.PAX8 antibody, also known as Paired box protein Pax-8 antibody or Pax-8 transcription factor antibody, recognizes a protein that produces a distinct nuclear staining pattern in tissue sections. In immunohistochemistry, this nuclear signal enables clear visualization of epithelial cell populations within intact tissue architecture, allowing differentiation between PAX8-positive tumor cells and surrounding stromal or inflammatory components. This is particularly important in diagnostic contexts where nuclear localization must be unambiguous and reproducible.PAX8 Antibody for IHC is uniquely positioned for large-scale tissue evaluation, with clone MSVA-708R supported by extensive human tissue microarray (TMA) data. Across normal tissues, strong nuclear staining is observed in thyroid follicular epithelium, renal tubular epithelial cells, and Mullerian-derived tissues including fallopian tube and endometrium, while most other tissues remain negative or show minimal background. This restricted staining pattern reinforces the specificity of PAX8 as a lineage marker in FFPE sections.In cancer tissue microarrays, clone MSVA-708R demonstrates consistent nuclear positivity in tumors of thyroid, renal, and gynecologic origin, including papillary thyroid carcinoma, renal cell carcinoma, and ovarian epithelial tumors. Importantly, negative staining is observed in many non-related tumor types, supporting its value in differential diagnosis. The ability to distinguish tumor origin based on nuclear staining patterns makes this antibody particularly relevant for pathology-driven applications where tissue context and staining contrast are critical.The recombinant rabbit monoclonal format of clone MSVA-708R supports strong, clean nuclear staining with minimal cytoplasmic background in FFPE samples. This enhances interpretability in both low- and high-expression tissues and allows reliable comparison across large TMA cohorts. PAX8 Antibody for IHC therefore provides a robust tool for tissue-based studies requiring precise nuclear localization, lineage identification, and high-confidence interpretation within preserved histological architecture.This antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.