Anti-Pax8 (C-Term) Rabbit Monoclonal Antibody (Clone RM436)

Paired box (Pax) protein 8 (Pax8) is a transcription factor and member of the Pax family that functions as both a transcriptional activator and repressor and has an essential role in thyroid development. It is composed of a DNA-binding paired domain, conserved octapeptide, partial homeodomain, transactivation domain, and an inhibitory domain. Alternative splicing of PAX8 pre-mRNA encoding the C-terminus results in five isoforms with varying DNA-binding capabilities and transcriptional activities. Pax8 is expressed during the mesenchymal-to-epithelial transition in the development of various organs and localizes to the nucleus. It is involved in cell survival, differentiation, and stem cell lineage commitment. Knockout of Pax8 produces smaller thyroids without follicles in mice. PAX8 mutations have been found in patients with thyroid dysgenesis, and chromosomal translocations leading to the fusion of PAX8 with PPARG, resulting in expression of Pax8-PPARgamma fusion proteins, are associated with follicular thyroid carcinomas. Cayman's Pax8 (C-Term) Rabbit Monoclonal Antibody (Clone RM436) can be used for immunohistochemistry (IHC).Synonyms: Paired Box Protein 8. Immunogen: A peptide from the C-terminal region of human Pax8. Clone Designation: RM436. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC. Cross Reactivity: (+) Pax8.