Anti-PAX7 / Paired box protein 7

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PAX7 antibody detects Paired box protein 7, a transcription factor critical for myogenesis, neural crest formation, and satellite cell maintenance. PAX7 belongs to the paired box family of transcriptional regulators that control early developmental programs through DNA binding and transcriptional activation. The PAX7 antibody is widely used in developmental and muscle biology to study stem cell regulation and tissue regeneration.PAX7 is encoded by the PAX7 gene located on human chromosome 1p36.13. The protein contains a paired DNA-binding domain, a homeodomain, and a C-terminal transactivation domain. During embryonic development, PAX7 is expressed in neural crest cells and the myogenic progenitor population of the somites. In adults, it marks quiescent muscle satellite cells responsible for postnatal muscle repair and regeneration.The PAX7 antibody identifies a 55 kilodalton nuclear protein by western blot and demonstrates strong nuclear staining in satellite cells and developing muscle fibers. Loss of PAX7 disrupts myogenic lineage specification, resulting in impaired muscle growth. Functionally, PAX7 activates myogenic regulatory factors such as MYOD and MYF5 and promotes self-renewal of satellite cells through repression of differentiation pathways.Beyond muscle tissue, PAX7 contributes to neurogenesis, pituitary development, and craniofacial patterning. Dysregulation of PAX7 is linked to rhabdomyosarcoma, where gene fusions with FOXO1 create oncogenic transcriptional drivers. NSJ Bioreagents provides a validated PAX7 antibody, enabling precise detection of muscle progenitors and developmental regulators.