Anti-Pax-5, clone YN01286m

B cell line specific activator protein (BASP, Pax-5). In the early stage of B cell development, Pax-5 can affect the expression of CD19, CD20 and other B cell specific genes. The protein plays an important role in the development of B cells and neurons. It is mainly expressed in the nucleus of pre-B cells and mature B cells, but not expressed in plasma cells, it is weak expression of R-S cells in Hodgkin's lymphoma and negative expression of T cells and tumors from which they are derived. It is mainly used for the judging of B cells and tumors from which they are derived. Protein function: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage- specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin- release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238). [The UniProt Consortium]