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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ATA-HPA012063.25 | 25 µl | - |
7 - 10 business days* |
300.00€
|
|||
| ATA-HPA012063.100 | 100 µl | - |
7 - 10 business days* |
421.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate... more
Product information "Anti-PARP14"
Protein function: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:27796300, PubMed:18851833, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP- ribosylates STAT6, enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 56% and to rat: 53%
| Keywords: | Anti-ARTD8, Anti-PARP-14, Anti-Poly [ADP-ribose] polymerase 14, Anti-B aggressive lymphoma protein 2, Anti-Protein mono-ADP-ribosyltransferase PARP14, Anti-ADP-ribosyltransferase diphtheria toxin-like 8 |
| Supplier: | Atlas Antibodies |
| Supplier-Nr: | HPA012063 |
Properties
| Application: | ICC, IHC |
| Antibody Type: | Polyclonal |
| Conjugate: | No |
| Host: | Rabbit |
| Species reactivity: | human |
| Immunogen: | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: AKEQESRADC ISEFIEWQYN DNNTSHCFNK MTNLKLEDAR REKKKTVDVK INHRHYTVNL NTYTATDTKG HSLSVQRLTK SKVDIPAHWS DMKQQNFCVV ELLPSDPEYN TVASKFNQTC S (ATA-APrEST71522) |
Database Information
| KEGG ID : | K15261 | Matching products |
| UniProt ID : | Q460N5 | Matching products |
| Gene ID | GeneID 54625 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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