Anti-PARK7 (CAP1, Oncogene DJ1, Parkinson Disease (Autosomal Recessive Early Onset) 7, RNA Binding P

Anti-PARK7 (CAP1, Oncogene DJ1, Parkinson Disease (Autosomal Recessive Early Onset) 7, RNA Binding P
Item number Size Datasheet Manual SDS Delivery time Quantity Price
031417.100 100 µl - -

3 - 19 business days*

606.00€
 
DJ-1, also known as Park7, is a cytoplasmic protein that belongs to the ThiJ/Pfp1/DJ1 superfamily... more
Product information "Anti-PARK7 (CAP1, Oncogene DJ1, Parkinson Disease (Autosomal Recessive Early Onset) 7, RNA Binding P"
DJ-1, also known as Park7, is a cytoplasmic protein that belongs to the ThiJ/Pfp1/DJ1 superfamily that function as protein chaperones, catalases, proteases and kinases. DJ-1 was originally cloned as an oncogene that cooperatively transforms cells together with H-ras (1). Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson's disease (2). DJ-1 may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death (3-5). Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke (6). The HGNC name for this protein is PARK7. Applications: Suitable for use in Immunocytochemistry, Immunofluorescence and Western Blot. On blots 031417 reveals a prominent ~21kD band, and on cells in tissue culture the antibody stains mainly in cytoplasm. Other applications not tested. Recommended Dilution: Immunofluorescence: 1:5000, Western Blot: 1:5000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: 031417

Properties

Application: ICC, IF, WB
Antibody Type: Monoclonal
Clone: 13B851
Conjugate: No
Host: Mouse
Species reactivity: bovine, human, mouse
Immunogen: Full length recombinant human DJ-1 expressed in and purified from E. coli.
Purity: Purified by affinity chromatography.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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