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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
031417.100 | 100 µl | - | - |
3 - 19 business days* |
606.00€
|
DJ-1, also known as Park7, is a cytoplasmic protein that belongs to the ThiJ/Pfp1/DJ1 superfamily... more
Product information "Anti-PARK7 (CAP1, Oncogene DJ1, Parkinson Disease (Autosomal Recessive Early Onset) 7, RNA Binding P"
DJ-1, also known as Park7, is a cytoplasmic protein that belongs to the ThiJ/Pfp1/DJ1 superfamily that function as protein chaperones, catalases, proteases and kinases. DJ-1 was originally cloned as an oncogene that cooperatively transforms cells together with H-ras (1). Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson's disease (2). DJ-1 may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death (3-5). Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke (6). The HGNC name for this protein is PARK7. Applications: Suitable for use in Immunocytochemistry, Immunofluorescence and Western Blot. On blots 031417 reveals a prominent ~21kD band, and on cells in tissue culture the antibody stains mainly in cytoplasm. Other applications not tested. Recommended Dilution: Immunofluorescence: 1:5000, Western Blot: 1:5000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: | United States Biological |
Supplier-Nr: | 031417 |
Properties
Application: | ICC, IF, WB |
Antibody Type: | Monoclonal |
Clone: | 13B851 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | bovine, human, mouse |
Immunogen: | Full length recombinant human DJ-1 expressed in and purified from E. coli. |
Purity: | Purified by affinity chromatography. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K05687 | Matching products |
UniProt ID : | Q99497 | Matching products |
Gene ID | GeneID 11315 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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