Anti-Parathyroid Hormone / PTH, clone MSVA-525R

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Parathyroid hormone (PTH), encoded by the PTH gene, is a peptide hormone produced primarily by chief cells of the parathyroid glands and plays a central role in calcium and phosphate homeostasis through regulation of bone resorption, renal calcium reabsorption, and vitamin D activation. Parathyroid Hormone Antibody for IHC recognizes this endocrine hormone and is designed for immunohistochemistry studies examining PTH expression in formalin-fixed paraffin-embedded tissues. PTH immunohistochemistry is widely used in endocrine pathology and cancer research to identify parathyroid tissue and to distinguish parathyroid-derived lesions from other neck or thyroid tumors.Parathyroid Hormone Antibody for IHC clone MSVA-525R is a recombinant rabbit monoclonal antibody developed for sensitive detection of PTH protein in tissue sections. Immunohistochemical detection of PTH is particularly valuable in the evaluation of parathyroid adenoma, parathyroid hyperplasia, and parathyroid carcinoma, where strong cytoplasmic staining of parathyroid chief cells can confirm hormone-producing endocrine tissue. In surgical pathology workflows, a PTH antibody is frequently used alongside markers such as GATA3, chromogranin A, and synaptophysin to characterize parathyroid lesions and differentiate them from thyroid follicular epithelium or metastatic tumors of the neck region.Within normal tissues, Parathyroid hormone is highly enriched in parathyroid gland cells, where it is synthesized as preproparathyroid hormone and processed into the mature secreted peptide hormone. Immunohistochemistry staining using a Parathyroid Hormone antibody typically demonstrates strong cytoplasmic signal in parathyroid endocrine cells, reflecting hormone synthesis and storage prior to secretion. Because parathyroid tissue is small and often difficult to identify histologically in surgical specimens, PTH immunohistochemistry provides a reliable molecular marker for confirming parathyroid origin in tissue sections and tumor samples.Recombinant rabbit monoclonal antibodies such as clone MSVA-525R are commonly selected for immunohistochemistry because of their high affinity and consistent epitope recognition, allowing clear visualization of hormone-producing cells in FFPE samples. Tissue microarray studies further support the specificity of Parathyroid Hormone Antibody for IHC by demonstrating expected staining patterns across multiple normal and tumor tissues, with signal largely restricted to parathyroid endocrine cells. This expression pattern aligns with published transcriptomic and proteomic datasets, reinforcing the value of PTH antibodies for endocrine pathology research, tumor classification studies, and tissue microarray-based immunohistochemistry screening.This PTH antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.