Anti-PANX3 / Pannexin 3

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PANX3 antibody detects Pannexin 3, a membrane channel-forming glycoprotein that mediates ATP release and cell communication. The UniProt recommended name is Pannexin 3 (PANX3). This protein belongs to the pannexin family, which forms hexameric channels in the plasma membrane, enabling the passage of ions and small metabolites involved in signaling and differentiation.Functionally, PANX3 antibody recognizes a 392-amino-acid integral membrane protein expressed predominantly in skin, cartilage, and bone. Pannexin 3 mediates ATP and ion fluxes that influence osteoblast differentiation, chondrocyte maturation, and keratinocyte communication. It also interacts with intracellular calcium signaling pathways, linking membrane excitability to tissue remodeling and growth.The PANX3 gene, located on chromosome 11q24.2, encodes a protein with four transmembrane helices, two extracellular loops with conserved cysteines, and intracellular N- and C-termini. PANX3 localizes to both plasma membrane and endoplasmic reticulum, participating in calcium homeostasis and metabolic coupling. Its expression is upregulated during endochondral ossification, contributing to skeletal development.Pathologically, abnormal PANX3 activity is implicated in osteoarthritis, cartilage degeneration, and abnormal bone formation. Overexpression enhances ATP release and promotes differentiation, while deficiency can impair mineralization and growth plate organization. In addition, pannexin signaling has been studied in cancer and inflammation for its role in autocrine ATP signaling and cell death regulation.PANX3 antibody is suitable for western blotting, immunofluorescence, and immunohistochemistry, making it a valuable tool for studies of bone biology, differentiation, and tissue communication. NSJ Bioreagents supplies PANX3 antibody reagents validated for use in osteogenic signaling and cellular communication research.Structurally, Pannexin 3 forms hexameric channels resembling connexins but does not form gap junctions. Instead, it functions as an ATP release channel regulated by voltage, phosphorylation, and extracellular calcium. Research with this antibody helps clarify PANX3's role in skeletal physiology and pathophysiology.