Anti-PAK6

Anti-PAK6
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R30819 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. p21 protein-activated kinase 6 is an... more
Product information "Anti-PAK6"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. p21 protein-activated kinase 6 is an enzyme that in humans is encoded by the PAK6 gene. This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding(CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor(AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. Protein function: Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR- mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. [The UniProt Consortium]
Keywords: Anti-PAK5, Anti-PAK6, Anti-PAK-6, Anti-PAK-5, EC=2.7.11.1, Anti-p21-activated kinase 6, Anti-Serine/threonine-protein kinase PAK 6, PAK6 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: R30819

Properties

Application: WB, IHC (paraffin)
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, rat, mouse
Immunogen: Amino acid sequence from the N-terminus of human PAK6 (QNFQHRVHTSFDPKEGK)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-PAK6"
Write a review
or to review a product.
Viewed