Anti-PAFAH1B2 / Platelet-activating factor acetylhydrolase IB subunit beta

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PAFAH1B2 antibody detects Platelet-activating factor acetylhydrolase IB subunit beta, an intracellular enzyme that regulates phospholipid metabolism and brain development. Encoded by the PAFAH1B2 gene on chromosome 11q23.3, this enzyme forms part of the trimeric PAF acetylhydrolase IB complex, which catalyzes the hydrolysis of platelet-activating factor (PAF) and other bioactive phospholipids. The complex consists of one regulatory subunit (LIS1/PAFAH1B1) and two catalytic subunits (PAFAH1B2 and PAFAH1B3), together maintaining membrane lipid homeostasis and neuronal signaling.PAFAH1B2 acts as a cytoplasmic serine hydrolase that removes acetyl groups from PAF, reducing its proinflammatory activity. Beyond lipid metabolism, it contributes to neuronal migration and brain development through its association with LIS1, which regulates microtubule dynamics and dynein-mediated transport. Mutations or dysfunction in components of this complex are associated with lissencephaly and neurodevelopmental defects.The PAFAH1B2 antibody is widely used in neuroscience, lipid signaling, and developmental biology research to investigate lipid hydrolysis, microtubule regulation, and neuronal migration. Western blot analysis identifies a 26 kilodalton band corresponding to PAFAH1B2, while immunofluorescence reveals cytoplasmic localization that overlaps with microtubule structures in neurons. This antibody enables detection of the catalytic subunit in both neuronal and non-neuronal tissues, supporting studies of phospholipid turnover and signaling.PAFAH1B2 also plays roles in inflammation and oxidative stress by modulating PAF levels. Abnormal expression has been linked to neuroinflammation and ischemic injury, as well as cancer metabolism where lipid mediators regulate proliferation. The PAFAH1B2 antibody provides a reliable reagent for exploring these processes. NSJ Bioreagents validates this antibody for western blotting and immunohistochemistry, ensuring accuracy for phospholipid and developmental signaling research.