Anti-PACSIN1 / Protein kinase C and casein kinase substrate in neurons protein 1

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The PACSIN1 antibody targets Protein kinase C and casein kinase substrate in neurons protein 1, a cytoplasmic protein encoded by the PACSIN1 gene. PACSIN1 belongs to the PACSIN family of F-BAR domain-containing proteins that regulate membrane curvature, endocytosis, and actin cytoskeleton remodeling. Expressed predominantly in neurons, this protein participates in synaptic vesicle recycling and the formation of dendritic spines. The PACSIN1 antibody is a key reagent for exploring how membrane trafficking and cytoskeletal dynamics shape synaptic function and neural connectivity.Protein kinase C and casein kinase substrate in neurons protein 1 contains an F-BAR domain that binds curved membranes and an SH3 domain that interacts with dynamin and synaptojanin. Through these interactions, PACSIN1 supports the fission of clathrin-coated vesicles during endocytosis. The PACSIN1 antibody allows detection of this neuronal scaffold protein in both cultured neurons and brain tissues, providing valuable insights into the molecular mechanisms of synaptic vesicle retrieval and recycling.PACSIN1 is essential for maintaining proper synaptic transmission and plasticity. Its loss disrupts vesicle endocytosis and actin dynamics, leading to impaired neuronal signaling. The PACSIN1 antibody enables researchers to examine protein expression and distribution across different brain regions, supporting studies of neurotransmission and dendritic spine architecture. It also helps identify post-translational modifications, such as phosphorylation by casein kinase and protein kinase C, that regulate its membrane association and function.In addition to synaptic processes, Protein kinase C and casein kinase substrate in neurons protein 1 has roles in endocytic trafficking in non-neuronal cells and participates in receptor internalization and signaling. Altered expression or mutation of PACSIN1 has been associated with neurological disorders including schizophrenia and neurodevelopmental delay, possibly through disrupted endocytic signaling and synaptic connectivity. The PACSIN1 antibody provides a means to analyze such pathophysiological changes at the protein level.Experimental applications for the PACSIN1 antibody include western blotting, immunofluorescence, and immunohistochemistry, where it reveals strong neuronal and synaptic staining. NSJ Bioreagents provides this antibody with validated specificity and consistency, ensuring reliable detection of Protein kinase C and casein kinase substrate in neurons protein 1. By supporting studies of synaptic organization, endocytosis, and neuronal plasticity, the PACSIN1 antibody is a critical reagent for advancing understanding of brain signaling and structural regulation.