Anti-p63, clone YN01256m

P63 gene is one member of the p53 gene family, which positions on chromosome 3q27-28, and encodes more than 6 major isomers that respectively treat transcriptional kinase activity, death induction activity (TAP63) and chromic inactivation activity. In embryo period, many kinds of epithelium and organs need P63 protein. P63 protein is expressed in myoepithelial cells and the effect is better than SMA, but is not expressed in myofibroblasts. Recent research shows that p63 is a marker of prostate basal cells, it is not expressed in the majority of prostate tumors, and its significance is similar to 34bE12. Since p63 is nuclear positive staining and P504S is cytoplasmic staining, the combination of them makes it easier to determine the results. Protein function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. [The UniProt Consortium]