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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R31164 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Ribonucleotide Reductase, M2 B, also known... more
Product information "Anti-p53R2"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Ribonucleotide Reductase, M2 B, also known as P53R2, is an enzyme that in humans is encoded by the RRM2B gene. Tanaka et al.(2000) mapped the gene to chromosome 8q23.1 by fluorescence in situ hybridization. Tanaka et al.(2000) found that expression of p53R2, but not R2, was induced by ultraviolet and gamma-irradiation and adriamycin treatment in a wildtype p53-dependent manner. Induction of p53R2 in p53-deficient cells caused G2/M arrest and protected cells from death in response to adriamycin. Inhibition of endogenous p53R2 expression in cells that had an intact p53-dependent DNA damage checkpoint reduced ribonucleotide reductase activity, DNA repair, and cell survival after exposure to various genotoxins. Protein function: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. [The UniProt Consortium]
Keywords: | Anti-RRM2B, Anti-p53R2, Anti-P53R2, EC=1.17.4.1, Anti-TP53-inducible ribonucleotide reductase M2 B, Anti-Ribonucleoside-diphosphate reductase subunit M2 B, Anti-p53-inducible ribonucleotide reductase small subunit 2-like protein, p53R2 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R31164 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | An amino acid sequence from the C-terminus of human p53 reductase small subunit 2 (EGKTNFFEKRVSEYQ) was used as the immunogen for this p53R2 antibody (100% homologous in human, mouse and rat). |
Format: | Purified |
Database Information
KEGG ID : | K10808 | Matching products |
UniProt ID : | Q7LG56 | Matching products |
Gene ID | GeneID 50484 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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