Anti-p27Kip1 (Mitotic Inhibitor/Suppressor Protein), clone DCS-72.F6

Formulation: Purified Ab WITHOUT BSA and Azide at 1.0mg/ml. Cellular Localization: Cytoplasm, Endosome, Nucleus. Positive Control: Breast, Cervical or Colon Carcinoma., HeLa or MCF7 cells. Tonsil, MDA-MB-231, SK-BR-3, T47D, ZR75. Chromosome Location: 12p13.1. Protein Function: Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry [The Uniprot Consortium]