Anti-p120, clone YN01266m

The linker family includes alpha - Catenin, beta - Catenin, r-catenin and p120 catenin. P120 catenin is linked to E-cadherin in the cytoplasm near the cell membrane, forming a complex, which is stable and closely linked. If E-cadherin is absent, p120 catenin will accumulate in the cytoplasm. There is only a small amount of membrane expression in breast ductal carcinoma, but there is no p120 catenin accumulation in the cytoplasm. The can be used to differentiate breast lobular / ductal tumors. Protein function: Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). [The UniProt Consortium]