Anti-p120-Catenin (C-Term) Rabbit Monoclonal Antibody (Clone RM353)

p120-Catenin is a member of the armadillo repeat domain protein family with roles in cell adhesion and junction maturation, as well as in the regulation of Rho family GTPase activity. Alternative splicing of CTNND1 pre-mRNA produces 64 isoforms with isoform 1 and 3 most commonly expressed. p120 isoform 1 is composed of an N-terminal coiled-coil domain, a regulatory domain, an armadillo repeat domain that facilitates cadherin interaction, and a C-terminal tail and is expressed in mesenchymal and non-epithelial cells. p120-Catenin isoform 3 lacks the N-terminal coiled-coil domain and is primarily expressed in epithelial cells. p120-Catenin is localized in three subcellular pools, a membrane-associated cadherin-bound pool, a cytoplasmic pool that modulates Rho GTPases, and a nuclear pool that associates with the transcriptional repressor Kaiso. Isoform switching from p120 isoform 3 to isoform 1 is coordinated with the E-cadherin to N-cadherin switch that occurs during epithelial-to-mesenchymal transition (EMT). Loss of CTNND1 expression is positively correlated with disease activity in patients with active Crohn's disease or ulcerative colitis. Increased levels of cytoplasmic p120-catenin are correlated with late-stage disease, lymph node metastasis, and reduced survival in patients with colorectal cancer, as well as poor prognosis in patients with lung squamous cell carcinoma and adenocarcinoma. Cayman's p120-Catenin (C-Term) Rabbit Monoclonal Antibody (Clone RM353) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: Catenin (Cadherin-associated Protein) Delta 1, Delta-Catenin. Immunogen: Peptide from the C-terminal region of human p120-catenin. Clone Designation: RM353. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) p120-Catenin.