Anti-OX40 (human), Rabbit Monoclonal (RM313)

Recombinant Antibody. This antibody reacts to human OX40 (CD134). Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. OX40 receptor is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells. OX40 is a secondary co-stimulatory immune checkpoint molecule. OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40 expression can promote viral binding and renders cells permissive for viral entry, productive infection and syncytium formation. Stimulating the receptor can improve the response to a powerful virus vector and may be useful in vaccine development.