Anti-OSBPL3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA048401.25	25 µl		-		7 - 10 business days*		246.00€
ATA-HPA048401.100	100 µl		-		7 - 10 business days*		491.00€

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Protein function: Phosphoinositide-binding protein which associates with both cell and... more

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Product information "Anti-OSBPL3"

Protein function: Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 83% and to rat: 82%

Keywords:	Anti-ORP-3, Anti-OSBPL3, Anti-KIAA0704, Anti-OSBP-related protein 3, Anti-Oxysterol-binding protein-related protein 3
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA048401

Properties

Application:	ICC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: FPHEVNHFFS GSTITDSSSG VFDSISSRKR SSISKQNLFQ TGSNVSFSCG GETRVPLWLQ SSEDMEKCSK DLAHCHAYLV EMSQLLQSMD VLHRTYSAPA INA (ATA-APrEST91143)