Anti-ORMDL3 / ORM1-like protein 3

In 1X PBS, pH 7.4, with 0.09% sodium azide. ORM1-like protein 3 is a protein that is encoded by the ORMDL3 gene. It belongs to a family of proteins known as ORM proteins, which play a crucial role in regulating the levels of sphingolipids - a class of lipids that are involved in various cellular processes. In particular, ORMDL3 has been shown to be a key player in the regulation of sphingolipid synthesis, and aberrant expression of this protein has been implicated in a number of diseases, including asthma. Recent studies have revealed that ORMDL3 plays a critical role in the development of asthma. It has been shown that individuals with certain genetic variations that result in increased ORMDL3 expression are at a higher risk of developing asthma. Additionally, ORMDL3 has been shown to be involved in the regulation of immune responses in the lungs, with increased levels of this protein leading to inflammation and airway hyperreactivity - hallmark features of asthma. Protein function: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:20182505, PubMed:30700557, PubMed:37308477). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (PubMed:37308477). [The UniProt Consortium]