Protein function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. [The UniProt Consortium]
Human (Expected: Orangutan, Rhesus Monkey, Gorilla, Northern White-cheeked Gibbon)
synthetic peptide. The epitope recognized by A301-492A-T maps to a region between residue 200 and 230 of human origin recognition complex subunit 6 using the numbering given in entry NP_055136.1 (GeneID 23594).