Anti-ODF2 / Outer dense fiber protein 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. ODF2 antibody detects Outer dense fiber protein 2, encoded by the ODF2 gene on chromosome 9q34.11. ODF2 antibody is used to study this coiled-coil structural protein, which is a key component of outer dense fibers in the sperm tail and the centrosomal appendages of somatic cells. ODF2 provides structural support to sperm flagella, ensuring integrity during motility, and contributes to centrosome function, microtubule anchoring, and ciliogenesis. Its dual role in reproductive biology and cell cycle regulation makes ODF2 a protein of wide research interest.Structurally, ODF2 is a coiled-coil protein that assembles into filaments. In sperm, ODF2 filaments wrap around axonemal microtubules, forming outer dense fibers that stabilize the flagellum and protect it against mechanical stress. In somatic cells, ODF2 localizes to subdistal and distal appendages of centrioles, where it serves as a scaffold for proteins involved in ciliogenesis and microtubule anchoring. This dual localization underscores ODF2's evolutionary adaptation from reproductive structures to general centrosome biology.Functionally, ODF2 plays a critical role in sperm motility and fertility. Knockout mouse models show that absence of ODF2 leads to abnormal sperm tails, defective motility, and infertility. In somatic cells, loss of ODF2 disrupts ciliogenesis, impairs microtubule organization, and causes defects in signaling pathways mediated by primary cilia. ODF2 is also required for centriole maturation and stability, influencing mitotic spindle organization and accurate chromosome segregation. Researchers use ODF2 antibody to study these processes in reproductive biology and cell cycle regulation.Clinically, mutations or altered expression of ODF2 are associated with male infertility syndromes and ciliopathies, including primary ciliary dyskinesia. Dysregulation of ODF2 may also contribute to cancer through defective centrosome function, leading to chromosomal instability. Expression studies using ODF2 antibody demonstrate strong staining in testis and centrosome-associated structures in diverse tissues. NSJ Bioreagents offers ODF2 antibody to support investigations into sperm biology, centrosome function, and ciliary signaling.