Anti-OCRL

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA012495.25	25 µl		-		7 - 10 business days*		320.00€
ATA-HPA012495.100	100 µl		-		7 - 10 business days*		450.00€

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Protein function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol... more

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Product information "Anti-OCRL"

Protein function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 (PubMed:7761412, PubMed:15474001, PubMed:9430698, PubMed:10764818). Able also to hydrolyzes the 4-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:7761412, PubMed:25869668). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling (PubMed:22072788). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 97% and to rat: 99%

Keywords:	Anti-OCRL-1, Anti-Lowe oculocerebrorenal syndrome protein, Anti-Inositol polyphosphate 5-phosphatase OCRL, Anti-Inositol polyphosphate 5-phosphatase OCRL-1, Anti-Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA012495

Properties

Application:	WB, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: DYFLTISGNY LPSCFGTSLE ALCRMKRPIR EVPVTKLIDL EEDSFLEKEK SLLQMVPLDE GASERPLQVP KEIWLLVDHL FKYACHQEDL FQTPGMQEEL QQIIDCLDTS IPETIPGSNH SVAEALLIFL EALPEPVICY ELY (ATA-APrEST74368)