Anti-NUP98 (ADIR2, Nuclear pore complex protein Nup98-Nup96 precursor, NUP196)

Anti-NUP98 (ADIR2, Nuclear pore complex protein Nup98-Nup96 precursor, NUP196)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
N5378-61B.100 100 µg - -

3 - 19 business days*

699.00€
 
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which... more
Product information "Anti-NUP98 (ADIR2, Nuclear pore complex protein Nup98-Nup96 precursor, NUP196)"
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186kD precursor protein. This cleavage results in the 98kD nucleoporin as well as a 96kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants, however, not all variants have been fully described. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-ADAR2, Anti-Nucleoporin Nup96, Anti-Nucleoporin Nup98, Anti-96 kDa nucleoporin, Anti-98 kDa nucleoporin, Anti-Nuclear pore complex protein Nup96
Supplier: United States Biological
Supplier-Nr: N5378-61B

Properties

Application: ELISA
Antibody Type: Monoclonal
Clone: 4G2
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: NUP98 (AAH12906, 1-110aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-NUP98 (ADIR2, Nuclear pore complex protein Nup98-Nup96 precursor, NUP196)"
Write a review
or to review a product.
Viewed