Anti-NUMA

Anti-NUMA
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Bethyl is giving away a free permanent marker for every Bethyl purchase until supplies last!

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-509A-T 20 µl (2 blots) -

3 - 9 business days

125.00€
A301-509A-M 100 µl (10 blots) -

3 - 9 business days

290.00€
A301-509A 100 µl (20 µg) -

3 - 9 business days

430.00€
 
Protein function: Microtubule (MT)-binding protein that plays a role in the formation and... more
Product information "Anti-NUMA"
Protein function: Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein- dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5- bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24996901, PubMed:24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis. [The UniProt Consortium]
Keywords: Anti-NMP-22, Anti-NuMA protein, Anti-SP-H antigen, Anti-Nuclear matrix protein-22, Anti-Nuclear mitotic apparatus protein, Anti-Nuclear mitotic apparatus protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: A301-509A-T

Properties

Application: WB, IP, IHC-IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Gorilla, Chimpanzee, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A301-509A-T maps to a region between residue 900 and 950 of human nuclear mitotic apparatus protein 1 using the numbering given in entry NP_006176.2 (GeneID 4926).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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