Anti-NUCKS1 / Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Nuclear ubiquitous casein and cyclin-dependent kinases substrate is a protein that in humans is encoded by the NUCKS1 gene. This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. Protein function: Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D- loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). [The UniProt Consortium]