Anti-NRP2 (Vascular endothelial cell growth factor 165 receptor 2)

NRP2(Neuropilin-2), also called Npn2 or VEGF165R2, encodes a member of the neuropilin family of , receptor proteins. The soluble NRP2 was secreted as a 62.5-kD protein following transfection in , Chinese hamster ovary cells. The NRP2 gene is mapped on 2q33.3. The NRP2 gene contains 17 , exons and spans about 112 kb. Sema3b can act to repulse axons expressing neuropilin-2 and can , antagonize the repulsive action of Sema3a on axonal growth cones expressing neuropilin-1. This , protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Mice with , null mutations in genes encoding Sema3F, and its holoreceptor components Npn2 and plexin A3 , (PLEXA3), exhibit increased dentate gyrus granule cell and cortical layer V pyramidal neuron spine, number and size, and also aberrant spine distribution. Moreover, Sema3F promotes loss of spines and , excitatory synapses in dissociated neurons in vitro, and in Npn2-null brain slices cortical layer V and , dentate gyrus granule cells exhibit increased miniature excitatory postsynaptic current frequency. These , disparate effects of secreted semaphorins are reflected in the restricted dendritic localization of Npn2 to , apical dendrites and of Npn1 to all dendrites of cortical pyramidal neurons. UniProt Number: O60462, Gene ID: NRP2, Applications: Suitable for use in Western Blot. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.