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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
039145.200 | 200 µl | - | - |
3 - 19 business days* |
728.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the... more
Product information "Anti-NRG1, ID (NRG1, GGF, HGL, HRGA, NDF, SMDF, Pro-neuregulin-1, membrane-bound isoform, Neuregulin"
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains, and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells. Applications: Suitable for use in Immunohistochemistry, Flow Cytometry and ELISA. Other applications have not been tested. Recommended Dilution: Immunohistochemistry (FFPE): 1:50-1:100, Flow Cytometric: 1:10-1:50, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-GGF, Anti-NRG1 |
Supplier: | United States Biological |
Supplier-Nr: | 039145 |
Properties
Application: | ELISA, FC, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | NRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human NRG1. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K05455 | Matching products |
UniProt ID : | Q02297 | Matching products |
Gene ID | GeneID 3084 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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