Anti-NPFFR2 (Neuropeptide FF Receptor 2, G-protein Coupled Receptor 74, G-protein Coupled Receptor H

NPFF2, a 60kD transmembrane protein, is a G-protein coupled NPFF receptor & shares homology with the seven trans-membrane domain receptor super family. It has a tissue-restricted distribution and consists of a 147-residue-N-terminal domain, 7 transmembrane domains and a C-terminal domain. It binds NPFF and might play a role in pain modulation and opiate tolerance. Reports suggest NPFF2 binds Prolactin releasing peptide and mediates its signaling. Northern Blot analysis detected a high expression of NPFF2 transcript in placenta, testis, thymus and small intestine with a moderate expression in other tissues. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.