Anti-NPC1 / Niemann Pick C1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG59009.50	50 µg		-	-	6 - 14 business days*		551.00€

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Protein function: Intracellular cholesterol transporter which acts in concert with NPC2 and plays... more

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Product information "Anti-NPC1 / Niemann Pick C1"

Protein function: Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:9211849, PubMed:9927649, PubMed:10821832, PubMed:18772377, PubMed:27238017, PubMed:12554680). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol- binding pocket in the N-terminal domain of NPC1 (PubMed:9211849, PubMed:9927649, PubMed:18772377, PubMed:19563754, PubMed:27238017, PubMed:28784760). Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (PubMed:19563754). Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). [The UniProt Consortium]

Keywords:	Anti-Niemann-Pick C1 protein, Anti-NPC intracellular cholesterol transporter 1
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG59009

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	mouse, rat (Expected: human)
Immunogen:	Recombinant protein corresponding to A1022-F1278 of Human NPC1 / Niemann Pick C1
Format:	Antigen Affinity Purified