Anti-NP95/UHRF1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-470A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A301-470A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A301-470A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Multidomain protein that acts as a key epigenetic regulator by bridging DNA... more
Product information "Anti-NP95/UHRF1"
Protein function: Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD- type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair. [The UniProt Consortium]
Keywords: Anti-hNp95, Anti-UHRF1, Anti-hUHRF1, Anti-HuNp95, Anti-ICBP90, EC=2.3.2.27, Anti-Nuclear protein 95, Anti-RING finger protein 106, Anti-Transcription factor ICBP90, Anti-Nuclear zinc finger protein Np95, Anti-E3 ubiquitin-protein ligase UHRF1
Supplier: Bethyl Laboratories
Supplier-Nr: A301-470A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A301-470A-T maps to a region between residue 275 and 325 of human nuclear zinc finger protein Np95 (ubiquitin-like, containing PHD and RING finger domains, 1 ) using the numbering given in entry NP_001041666.1 (GeneID 29128).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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