Anti-NOTCH2

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ATA-HPA048743.25 25 µl -

7 - 10 business days*

300.00€
ATA-HPA048743.100 100 µl -

7 - 10 business days*

421.00€
 
Protein function: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2... more
Product information "Anti-NOTCH2"
Protein function: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 87% and to rat: 86%
Supplier: Atlas Antibodies
Supplier-Nr: HPA048743

Properties

Application: ICC, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: PGILQASPNP MLATAAPPAP VHAQHALSFS NLHEMQPLAH GASTVLPSVS QLLSHHHIVS PGSGSAGSLS RLHPVPVPAD WMNRMEVNET QYNEMFGMVL APAEGTHPGI APQSRPPEGK HITTPREPLP PIVTFQLIPK GSIAQ (ATA-APrEST88601)

Database Information

KEGG ID : K20994 | Matching products
UniProt ID : Q04721 | Matching products
Gene ID : GeneID 4853 | Matching products
Protein Atlas Nr. : ENSG00000134250

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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