Anti-Nogo-A B

Anti-Nogo A/B Antibody is sera. A BLAST analysis was used to suggest cross-reactivity withAnti-Nogo-A B from human, mouse, and rat based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Nogo-A B from other sources has not been determined. Protein function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. [The UniProt Consortium]