Anti-Nod2 (Clone 2D9)

Nod2 is a member of the apoptosis regulating protein family that has caspase recruitment-domains (CARDs) and also includes Apaf-1 and Nod1. Nod2 contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). Nod2 is expressed in monocytes whereas Nod1 (CARD4) is expressed in multiple tissues. Both Nod1 and Nod2 act as intracellular receptors for bacterial lipopolysaccharides, activate NF-kB, and contribute to inflammatory bowel disease. A frameshift mutation in the NOD2 gene is associated with susceptibility to Crohn's disease, possibly by causing truncation of the tenth LRR. Cayman Chemical's NOD2 Monoclonal Antibody can be used for Western blot and immunohistochemical analysis of Nod2 on samples of human origin. The antibody will also recognize three Nod2 polymorphisms: L1007finsC, G908R, and R702W.Synonyms: Caspase Recruitment Domain-containing Protein 15, Inflammatory Bowel Disease Protein 1, Nucleotide-binding Oligomerization Domain-containing Protein 2. Immunogen: Recombinant protein fragment from the internal region of human Nod2. Clone Designation: 2D9. Formulation: (Request formulation change), 200 µg of ammonium sulfate-purified monoclonal antibody. Storage Buffer: PBS, pH 7.4, with 0.02% sodium azide. Host: Mouse. Isotype: IgG1kappa. Applications: WB. UniProt Accession #: Q9HC29. Origin: Animal/Mouse.